Chunk #6 — Variant calling and Quality Control filtering of exome sequencing datasets

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Exome sequencing and the genetic basis of complex traits.

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For this Perspective, we generated whole-exome data (targeting 28 Mbp) from 438 samples (see Methods section) using a two-stage approach52, 53. First, we applied the data processing and variant calling protocol described previously54. Second, we applied post-SNP-calling Quality Control (QC) filters.