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Chunk #22 — Results

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Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence.
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Associations between the RVs and AD, CD and OD were evaluated using SKAT (Wu et al., 2011), for the 8271 subjects. The analysis was adjusted for age, sex and SD phenotypes (when one SD phenotype was used as the outcome, the other two phenotypes were adjusted in the model).