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Chunk #1 — Introduction

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Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America.
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et al., 2005; Marchini, et al., 2004). Methods to measure, and therefore address differences in population structure in association testing have been developed (Epstein, et al., 2007; Hoggart, et al., 2003; Price, et al., 2006; Pritchard, et al., 2000b; Purcell, et al., 2007; Satten, et al., 2001). In the context of whole genome association (WGA) scans, these methods can be readily applied. However, for follow-up association studies to further define critical candidate regions in larger population sets, or for analyses of additional populations, a small set of ancestry informative markers (AIMs) is highly desirable.