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Chunk #32 — Results — Illustrative Application

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Resource profile and user guide of the Polygenic Index Repository.
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The results in Panel B illustrate a fairly general implication of the measurement-error correction for PGI-by-environment interaction analyses: in contrast to how it affects mediation estimates, the correction tends to increase the magnitude of PGI-by-environment interaction estimates. A main result of Papageorge and Thom is about two such interactions: a higher PGI is associated with a weaker relationship between childhood SES and high school completion but a stronger relationship between childhood SES and college completion20. Columns (1) and (2) reproduce two specifications that show this result: a regression of high school completion on the PGI, self-reported childhood SES, their interaction, and controls; and the analogous regression for college completion. The key finding is that the interaction term is negative in column (1) but positive in column (2). As shown in columns (3) and (4), once the additive SNP factor is considered instead of the PGI, the interaction coefficients for both the high school and college regressions move farther away from zero, strengthening the main result of the paper. In general, PGI-by-environment interaction studies that do not correct for measurement error