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Chunk #19 — RESULTS — Neuroimaging Results — Correlation of Resiliency with 2-back Task Related Regions

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Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood.
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Post-hoc analysis of extracted ROI data was conducted excluding subjects with any diagnosis of SUD, conduct disorder, or ADHD (n=7: two FH-/five FH+, resulting in n=60). Resiliency remained significantly correlated with both regions at p<0.005, confirming that effects of externalizing disorders were not driving these correlations. Additional post-hoc regression of resiliency with STN and pallidum activation maintained significance controlling for IQ (p’s<0.001) and gender (p’s<0.028).