We have been careful to state that the current genomic evidence is inconsistent with an association for a particular gene. This is an evolving area, and it is possible that genes not now associated with schizophrenia will transition to significance with on-going expansions of sample sizes for common and rare variation. None of the historical candidate genes can be unequivocally excluded as a genetic risk factor for schizophrenia. However, we can state with high confidence that the large common variant genetic effects originally reported in many initial candidate gene studies are highly unlikely to be true.
