To clarify the effect of rs1799971 on substance dependence risk, we conducted collaborative meta-analyses based on new analyses of multiple datasets. Our data-driven approach moves beyond the limitations of literature-based meta-analyses by (1) defining consistent phenotypes across studies, (2) performing new, uniform analyses across datasets as in our previous meta-analyses (Chen et al. 2012b; Hartz et al. 2012; Saccone et al. 2010), and (3) inviting investigators to contribute analyses from established studies with relevant phenotype and genotype data, irrespective of prior publication on rs1799971.
