The main findings are highlighted in Table 2. In the end, across all analyses, we discovered only a handful of significant associations, none of which survived correction for multiple testing across the 17 endophenotypes, and each of which requires replication. Novel variant discovery in this sample was far from a resounding success and ready replication is not available for the hits we did have. Table 2 lists the largest GWAS effect sizes associated with any of the over 500,000 examined variants, only one of which was significant. To achieve 80% power to detect a SNP with the median effect size of .58 reported in the Table, a sample size of 6,808 would be required. If we accumulated a sample this big, it would still not be large enough to detect the largest SNP for half the endophenotypes listed in Table 2, and for the other half, it would detect very few variants, thus contributing little insight into the molecular genetic basis of individual differences in any of these measures.
