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Chunk #17 — 3 Results — 3.3 Genome partition of common genetic variants — 3.3.1 Partitioning the genome by chromosome

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Exploring the genetic architecture of alcohol dependence in African-Americans via analysis of a genomewide set of common variants.
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We first estimated the genetic relationship matrix based on SNPs on each autosome using all individuals. Next we fitted a linear regression to explore the relationship between the number of known genes in a chromosome and its explained variance. This result is shown in the left panel of Figure 2. The R2 was 0.14% (P-value= 0.8685), indicating that there is no significant association between them. When we considered the relationship between the length of a chromosome and its explained variance, we observed a significant linear relationship between them (R2 = 20.75%, P-value= 0.033), as shown in the right panel of Figure 2.