role in alcoholic fatty liver than liver FR1 was not from a direct comparison between Fgf21alb-cre mice and Fr1alb-cre mice. Instead, by comparing Fgf21alb-cre mice and Fgf21fl/fl mice, we know that liver FGF21 plays an important role in alcoholic fatty liver and by comparing Fr1alb-cre mice and Fr1fl/fl mice, we conclude that liver FR1 has no effect on alcoholic fatty liver. Thus, liver FGF21 is more important than liver FR1 in alcoholic fatty liver.
