Youths who began consumption with cannabis scored 7 times higher on the TLI compared with youths whose first substance was alcohol. Thus, although transmissible liability is congenerous to AUD and CUD, there is a marked difference in magnitude of risk among youths who begin substance use with cannabis. Considering that cannabis use is universally proscribed, whereas alcohol is proscribed for only minors, consumption of this illegal drug requires a more severe manifestation of the liability consistent with the finding that nonnormative socialization mediates the association between transmissible risk in childhood and CUD in adulthood (Tarter et al., 2011).
