Chunk #45 — MATERIALS AND METHODS — CNV validation and replication — Validation of CNVR 11q11 by qPCR

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Novel common copy number variation for early onset extreme obesity on chromosome 11q11 identified by a genome-wide analysis.

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For further analysis of the CNVR 11q11 signal, in the independent sample of 365 obesity trios copy number status was also assessed by the qPCR assay described above, resulting in similar proportions for heterozygous and homozygous deletion carriers.