One possibility to explain our non-significant association with SZ of rs1344706 is insufficient power to detect a significant difference. In fact, the statistical power sufficient to replicate findings with relatively low relative risk is a critical determinant of the success of any replication study. An odds ratio of 1.38 and 1.23 was reported for association of SZ with rs1344706 and rs12476147, respectively (O'Donovan et al., 2008; Williams et al., 2011), and odds ratios are usually expected to be lower in replication studies. Our post-hoc power analysis shows that with the present sample size, the study has 35% and 44% power for the rs1344706 and rs12476147 SNPs respectively to detect a significant association.
