Rossi and colleagues(27) found a lower prevalence of high-risk cytogenetic lesions in individuals with MBL compared to those with Rai 0 CLL. Specifically, MBL cases had a lower prevalence of del(11q22)/del(17p13) (3.8% vs. 15.2%, P=0.004) and of TP53 mutations (3.0% vs. 11.5%, P=0.049) compared to those with Rai 0 CLL.(27) In contrast, the percentage and prevalence of IGHV gene identity; distribution of IGHV genes; and prevalence of stereotyped HCDR3 did not differ significantly between MBL and Rai 0 CLL cases.(27) The expression patterns of CD38, ZAP70, and CD49d were not statistically different between the two groups.(27)
