was adjusted using available biological and methodological covariates in an attempt to reduce the influence of systematic confounding effects (Text S1). Post hoc we annotated significant QTLs as cis if the SNP lay within 1MB of either the CpG methylation site in question or the transcript being tested; all other SNP-dependent variable tests were designated as trans. Notably, because designation of cis and trans QTL tests was performed post hoc, there was no distinction in terms of level of statistical correction between these groups.
