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Chunk #10 — 2. Methods — 2.1. Subjects and phenotype assessment

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Associations of glutamate decarboxylase genes with initial sensitivity and age-at-onset of alcohol dependence in the Irish Affected Sib Pair Study of Alcohol Dependence.
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Interviews were conducted by clinically trained research interviewers, most of whom had extensive clinical experience with alcoholism. The interview included demographic characteristics, lifetime history of AD and alcohol-related traits, and comorbid conditions. DSM-IV AD was assessed using the SSAGA (Semi-Structured Assessment of the Genetics of Alcoholism) interview (version II, Bucholz et al., 1994) modified to reduce assessment time by omitting items that address onset age of each symptom.