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Chunk #47 — Methods — Development of Hi-C coupled MAGMA (H-MAGMA)

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A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles.
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regions were overlapped with Gencode v26 exon and promoter coordinates to identify exon- and promoter-based interactions. We used exon- and promoter-based interactions, because our previous study comparing Hi-C data with eQTLs have demonstrated the gene regulatory potential of exon-level interactions3. Hi-C data from brain homogenate (fetal and adult human brain) and brain cells (hiPSC-derived neurons and astrocytes) were used to generate MAGMA input files that describe gene-SNP pairs. Input files can be found in the github repository: https://github.com/thewonlab/H-MAGMA.