replicates were genotyped and produced a concordance rate of 100%. All 10 SNPs were successfully genotyped for 96% of the samples. Because allele frequencies and linkage disequilibrium structures often differ across populations, we limited all analyses and data in this study to the subsample of white individuals (n=378; 190 men, 188 women). Haploview40 was used to estimate linkage disequilibrium across the genotyped SNPs. As in previously genotyped samples, linkage disequilibrium was very high, with r2 ranging from 0.81 to 1.00 (mean r2=0.91).41 This indicates that the SNPs are highly correlated and do not represent independent tests of association. Table 1 displays descriptive information on each of these SNPs, including chromosomal position estimates from the SNP database (dbSNP) and minor allele frequencies. All SNPs were in Hardy-Weinberg equilibrium.
