As previously reported [21],[48],[49], relative to comparable lattice and completely random graphs, the adult graph architecture showed high clustering coefficients and short path lengths, consistent with the ‘small world’ architecture (Figure 3B and 3C). Interestingly for these networks, in children (i.e., as early as age 8), these metrics were quite similar to adults (Figure 3B and 3C), and over age there was very little change in path lengths and clustering coefficients relative to comparable random and lattice graphs. It was originally anticipated that path lengths would decrease over age as long-range anatomical connections were added. Yet even at the youngest ages examined, path length was already quite short, near those of random graphs. Importantly, these results were not dependent on any particular threshold (Figure S5). We note that while the results shown here are largely descriptive, the error bars provided in Figure 3B and 3C constructed from random graphs underscores the difference between random configurations and the observed trends.
