Individuals with TS or OCD were recruited as part of collaborative efforts to conduct the first GWAS for these disorders (details in Scharf et al, 2013; Stewart et al, 2013) (15, 16). Although data were collected independently for TS and OCD, all genotyping and data cleaning were done together, facilitating joint analyses. Participants ≥18 years of age provided written, voluntary informed consent. Individuals under 18 years of age provided assent; written parental consent for their participation was also obtained. The study was approved by the Ethics Committees of all participating sites and in accordance with the Declaration of Helsinki. For the cross-disorder analyses, any subject with either TS or OCD was considered affected. See Supplementary Methods for details of the inclusion and exclusion criteria and assessment protocols.
