Such an approach is not without challenges, including the need to design an intervention that could be delivered remotely (e.g., via web or app interface) in order to reach a geographically dispersed population. Further, there are limits to the level of malleability attainable, as documented in studies of children reared in orphanages who were subsequently adopted. Nonetheless, given the potential of personalized medicine approaches to spur new discoveries, there has never been a better time to integrate naturalistic experimental designs such as those described in this article into the burgeoning world of personalized medicine approaches.
