Following the identification of gene networks of relevance to GWAS findings (i.e., genes shown to interact with DSE via physical, co-expression, co-localization and/or pathway analyses in previous studies, curated using GeneMANIA as described above), gene-based analyses indicated that when considered as a set (all available SNPs in a given gene, corrected for the number of independent signals within that gene set), variants within the following genes are associated with fast beta EEG (empirical p-value<0.05): DSE, ZEB2, MCTP1, RND3 and CTBP2 (Table 3). In addition, gene-based analyses indicated that ZEB2 and CTBP2 were also associated with DSM-V AUD (empirical p-value<0.05; Table 3). Table 3 details the number of variants examined in each gene-set, the number of variants nominally associated with beta EEG and/or AUD (p<0.05), the number of independent signals represented among each of the SNPs tested, and the empirical p-value based on 100,000 permutations. In addition, 20/26 GABRA2 variants previously shown to be associated with aspects of beta EEG were modestly (p<0.05) associated with fast beta EEG at specific fronto-central pairs (Table 4). Of these 20 variants, 5 survive a multiple-test correction (0.05/3 LD Blocks: p<0.017).
