AFT to the motor-impairing effects of ethanol is associated with a reduction in the ability of ethanol to enhance muscimol-stimulated Cl− uptake in cerebellar microsacs (Wallace et al. 2007). Studies in GABAA receptor genetically modified models have shown that AFT to motor incoordination is decreased in γ2S- and γ2L-GABAA receptor transgenics (Wick et al. 2000), but does not differ in α1-, α5-, α6-, γ2L-, or δ-GABAA receptor knockout mice (Boehm et al. 2004b; Homanics et al. 1998, 1999a; Kralic et al. 2003; Mihalek et al. 2001). However, recent work in α1-GABAA receptor (S270H, L277A) knockin mice suggests that α1-GABAA receptors are involved in AFT to ethanol (Werner et al. 2009), since these mice display decreased AFT to motor coordination.
