disorder do not correspond exactly to any of the specific diagnoses of DSM-IV or ICD-10, but HADS includes certain ICD-10 features [11,20]. In particular, HADS-D focuses on anhedonia, by some viewed as a core symptom of depression [14], while the HADS-A subscale mainly captures features of generalized anxiety [21]. Recently, it has been suggested that HADS-A covers two dimensions, i.e. negative affectivity and autonomic arousal [37]. A separate evaluation of these two dimensions was not possible, and as a consequence, we can not rule out a possible positive association between the Val158Met polymorphism and negative affectivity or autonomic arousal, respectively.
