A recent collaborative GWA study (17) that consisted of 4,387 cases and 6,209 controls pooled from the Wellcome Trust Case Control Consortium (13) Bipolar Analysis, Sklar et al. (STEP-BD) (16), and 2,365 new samples highlighted three regions of interest: ANK3 (ankyrin G), CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel), and a region 3.3kb away from C15ORF53 on chromosome 15q14 (17). This analysis was restricted to individuals of EA; therefore, we investigated these regions within only the EA sample in our study (Figure S3). When we focus on the top SNPs from this study that were directly genotyped in our study, only one of the SNPs reached p < 0.05 (ANK3, rs1938526/G, p = 0.036, OR = 1.31), although the top SNP in the 15q14 region approached p < 0.05 (rs2172835, p = 0.057, OR = 0.88). In both cases, the association was in the same direction and of a similar strength as previously reported. In both of these regions, we saw additional SNPs that showed low (0.01-0.0001) p-values.
