Taken together, we found enhanced resting-state functional connectivity within the regions related to reward, memory, craving and motivation, but reduced connections within the regions associated with cognitive control and craving and behavioral guidance in addictive drug users with fMRI. These findings suggest an abnormal functional organization in the addictive brain, which may provide additional evidence supporting the theory of addiction (Baler and Volkow, 2006; Bechara, 2005; Everitt and Robbins, 2005; Garavan and Hester, 2007; Goldstein and Volkow, 2002) that emphasizes enhanced salience value of a drug and its related cues but weakened strength of cognitive control in the addictive state.
