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Chunk #108 — Quantification and Statistical Analysis — Normalization of Connectivity Scores

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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
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To allow for comparison of connectivity scores across cell types and perturbation types, the scores are normalized to account for global differences in connectivity that might occur across these covariates. Given a vector of WTCS values w resulting from a query, we normalize the values within each cell line and perturbagen type to obtain normalized connectivity scores (NCS) as follows: