Finally, the top two SNPS located on chromosome 1 are also worth mentioning given that significant over-representation of KCNN3 alleles with longer CAG repeats have been previously reported in AN patients [Koronyo-Hamaoui et al., 2002, 2004]. The small-conductance calcium-activated potassium channel gene KCNN3 is expressed in brain; increased expression in the hippocampus has been associated with reduced long-term potentiation [Blank et al., 2003]. Although several studies have reported positive associations of increased CAG-repeat length of KCNN3 with schizophrenia and bipolar disorder, a recent meta-analysis casts doubt on this association, while leaving open the possibility that other aspects of this polymorphism may contribute to specific features of these disorders [Glatt et al., 2003].
