The PGC will systematically evaluate GRS in three contexts: (a) development: use data from large longitudinal cohorts to evaluate the developmental effects of GRS; (b) clinical: analyze relationship between clinical descriptors/symptoms (e.g., early vs late onset, severer vs milder, or unremitting vs episodic illness) and GRS to understand clinical relevance; and (c) analyze GRS by environment interactions in epidemiological samples.
