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Chunk #10 — Methods — Participants

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The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach.
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The present sample included 1591 unrelated individuals from the Study of Addiction: Genetics and Environment (SAGE; Bierut et al., 2010) who reported having ever used cocaine; the mean age of these cocaine users was 38.25 years (SD = 7.6, range = 18 - 63), 42.6% were female, and 37.5% and 4.05% self-reported African or Hispanic ancestry (versus European or non-Hispanic ancestry), respectively. SAGE was designed to examine the genetic underpinnings of alcohol dependence, with participants drawn from three primary studies: FSCD, the Family Study of Cocaine Dependence (Bierut et al., 2008); COGA, the Collaborative Study on the Genetics of Alcoholism (Begleiter et al., 1995); and COGEND, the Collaborative Genetic Study of Nicotine Dependence (Bierut, 2007). All data used in the present study are available via the database of Genotypes and Phenotypes (dbGaP; phs000092.v1.p1).