At the time of writing, this paper was the first attempt to spectroscopically assess the impact of the glutamatergic system modulators, particularly sarcosine, on metabolite concentrations in the DLPFC in patients with schizophrenia. Significant changes in the spectral characteristics co-occurring with alleviation of symptoms, assessed with the PANSS scale, imply that two grams of sarcosine daily sufficiently penetrates the blood-brain barrier to modify the neuronal activity in patients with schizophrenia. Moreover, significant negative correlations between differences in negative PANSS subscale score and spectroscopic parameters (NAA/Cho and mI/Cho ratios) suggest that these ratios might quantitatively correspond with clinical outcomes of therapeutic intervention.
