Family history of DSM‐5 AUD was ascertained for adult subjects and adult family members through the SSAGA, and adolescents through the child and adolescent tailored CSSAGA (Bucholz et al., 1994). A FHD ratio was calculated for each individual from both alcohol and community control families, with reported information for four or more relatives (N = 1,704). We note that while those from community comparison families had lower FHD scores on average, compared with those ascertained from families densely affected with alcohol dependence (mean FHD[SD]: 0.299[0.152] vs. 0.513[0.154]), many had scores > 0 and all participants were included in these analyses. Details regarding the calculation of FHD can be found in Pandey et al. (2020). Briefly, affectedness was defined as the individual's first‐ and second‐degree relatives’ (parents, grandparents, parental siblings, full siblings, half‐siblings) AUD symptom count values divided by the maximum possible value of 1 (range from 0 to 1). Weighting was applied, such that the weight decreases with the increase in degree of relatedness. This measure, referred to as FHD in this study, has been found to be a sensitive indicator of individuals with DSM‐IV alcohol dependence (Pandey et al., 2020).
