to be significantly regulated in the nucleus accumbens19 and dorsolateral prefrontal cortex21 of human cocaine users and in diverse cortical regions in alcoholic cases.17–18,24–25 Changes in PLP1 expression was also identified in schizophrenic cases.29–31 Such changes in oligodendroglial metabolism and function may significantly impact neural communication, including glutamatergic neurotransmission32, and be compounded by transcriptional changes functionally associated with lipid metabolism and function19,21–22,31,33, affecting lipid-mediated synaptic function, signal transduction and intracellular messenger cascades.
