Chunk #72 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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O. Sample 15) African American individuals (ages 18 – 65) with different levels of general cognitive ability as assessed by the Shipley Institute of Living scale. Research volunteers with a variety of different levels of lifetime use of addictive substances volunteered for research protocols at the NIH (NIDA) facility in Baltimore, Maryland, as described above. Eighteen pools were constructed with DNA from 20 individuals each (33% female, average age 32.1). Mean cognitive function scores estimated from Shipley Institute of Living scales ranged from “IQ” equivalents of 75.9 to 109.2 for the individuals in these DNA pools.