The overall genotyping success rate was 98.4%. Allele frequencies were analyzed for deviations from Hardy-Weinberg equilibrium (HWE), which can be an indication of genotyping problems or stratification. No deviations from HWE were detected. Additional details about the genotyping in CDP are available elsewhere (Dick et al., 2009). Table 1 contains additional descriptive information about the SNPs, including their relative location within the gene—as derived from estimates of chromosomal position within the dbSNP (Mailman et al., 2007) database—and marker-specific major and minor nucleotide bases with corresponding allele frequencies. Because allele frequencies and correlation structures between SNPs in a gene often differ across populations, we limited all analyses and data reported in this article to the subsample of Caucasian individuals (N = 374; 189 male, 185 female).
