Most genes were found to be significantly associated in a handful of tissues as illustrated in Fig. 8b. For example, for LDL-C levels, liver was the most enriched tissue in significant associations as expected given known biology of this trait (See Supplementary Fig. 5). This prominent role of liver was apparent despite the smaller sample size available for building liver models (n = 97), which was less than a third of the numbers available for muscle (n = 361) or lung (n = 278).
