Chunk #20 — Results — GWAS results from the discovery sample — Smoking initiation

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Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.

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In the total sample, two SNPs, rs1442815 and rs11134474, located in the gene desert region on chromosomes 15q26 and 5q33, respectively, were associated with SI-1 and SI-2, respectively. Further analysis of the male sample revealed six more SNPs with SI-1 or SI-2 with p values <10−5: rs7761503, rs7747583, and rs2349433, located in RGS17 on chromosome 6; rs10511914 in DCAF12, located on chromosome 9; and rs1385706 and rs12534697, located in an intergenic region at 7q11.