near NEGR1, in SORCS3 and in the HIST1 histone cluster, respectively. Among the novel loci, the three strongest associations were in BPTF, LINGO1 and GRIA1 (Table 1). All three genes have been associated with monogenic forms of neurodevelopmental disorders32-34 and GRIA1, encoding glutamate ionotropic receptor AMPA type subunit 1 (GluA1), implicates a role of AMPA receptors in the etiology of depression. We also note that the seventh-strongest novel locus is located in GABRA1, which suggests a role of GABA receptors in developing depression. Both AMPA and GABA receptors are targets for antidepressants35,36.
