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Chunk #1 — Introduction

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The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010.
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Historically, major health policy decisions have been informed by mortality statistics. Although our understanding of diseases causing premature mortality expanded as a result, the lack of emphasis on morbidity undervalued the global impact of prevalent and disabling disorders with lower mortality, such as mental, neurological, and substance use disorders. Until recently, there was a poor understanding of the comparative global epidemiology of mental, neurological, and substance use disorders and slower progress compared to other disorders in identifying the most cost-effective interventions. Although these disorders exist in all countries, cultures also influence their development and presentation. The predominantly Western-based definitions of mental, neurological, and substance use disorders can be in conflict with cultural contexts[5], leading to challenges in assembling data on global epidemiology. For example, some languages do not have the words to describe concepts such as “sadness” or “depression” as they are described in Western countries. Epidemiological surveys in many LMICs tend to capture somatic manifestations of disorders such as depression and anxiety, which may not be as relevant to other countries and cultures [6–8]. Furthermore, explanations for the onset