Another perspective on the multiple testing problem is that the family-wise error rate is not the most appropriate measure, and that other measures should be used that have better sensitivity and specificity in genome-wide studies. Although weak control of FWER for the overall significance has been advocated, some error control for the single tests is also desirable. Here, two prominent alternatives are discussed: false discovery rates (FDRs)[52,53] and posterior error rates [54,55].
