Chunk #7 — METHODS AND MATERIALS — Genotype Imputation

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Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.

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then split into AA and EA datasets based on the clustering techniques described above. We retained 18,564,419 SNPs with derived information content >.8 in at least one of the population groups. After excluding SNPs with MAF < 3% in both AAs and EAs, 11,995,908 SNPs common to both discovery datasets (11,106,284 in AAs, 7,535,791 in EAs) were included in association analyses.