As expected, the newer arrays, with a subset of probes specifically targeting CNVs, outperformed older arrays both in terms of the number of calls and the reproducibility of those calls. Analysis of the deviation in breakpoint estimates (based on number of probes) shows that this difference is not only due to an increased resolution, but is also consistent with increased individual probe performance in the newer arrays. These results highlight that newer arrays provide more accurate data, whether the focus is on smaller or larger variants.
