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Chunk #0 — Introduction

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Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.
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Smoking is a major risk factor for lung cancer, cardiovascular and respiratory diseases making it the leading cause of preventable death worldwide (World Health Organization, 2011). In developed nations, smoking is more common amongst individuals with mental health conditions (Coulthard, Farrell, Singleton, & Meltzer, 2002; Lasser et al., 2000; Lawrence, Mitrou, & Zubrick, 2009; McClave, McKnight-Eily, Davis, & Dube, 2010), in particular schizophrenia (Royal College of Physicians, 2013) and depression (Byers et al., 2012; Leung, Gartner, Dobson, Lucke, & Hall, 2011; Tjora et al., 2014). In the UK, estimates suggest that up to 45% of individuals with schizophrenia, and 31% of individuals with depression smoke (Royal College of Physicians, 2013), compared with around 15% of the general population (Office for National Statistics, 2019). Individuals with mental health conditions smoke more heavily (Coulthard et al., 2002) and experience up to 18 years reduced life expectancy compared with the general population (Chang et al., 2011; Royal College of Physicians, 2013). Much of this reduction can be explained by smoking-related diseases (Royal College of Physicians, 2013), making it important to understand the relationship between smoking and mental health.