Chunk #21 — Results — Deleting Zfhx1b in SVZ of the MGE Using DlxI12b-Cre Phenocopies Loss of Zfhx1b function in the VZ (Nkx2.1-Cre) — Postnatal Analysis of cortical and striatal interneuron phenotypes in Nkx2.1-Cre;Zfhx1b mutants
In the striatum at P0, as we saw at E15.5, there was an increase in the number of cells expressing EGFP (Cre reporter), Sst and Lhx6 (Figure 4G-4I’); consistent with the hypothesis that Zfhx1b mutant cells that were destined to go to the neocortex, instead migrated to the striatum. Additionally, there was a clear increase in the number of striatal cells expressing nNos, NPY and Nkx2-1 (Figures 4J-4K’, S4B and B’), while we observed no change in Lhx8, a marker for striatal cholinergic interneurons (Figures S4A and S4A’).
