Phenotype-specific lists of previously identified loci were hand-curated for each phenotype and included SNPs indexed in the GWAS Catalog or identified through non-GWAS high-throughput methods (for example, metabochip, exomechip or immunochip). The full lists of known loci for each phenotype are available in Supplementary Table 5. Conditional analyses were conducted for all phenotypes by conditioning on all previously identified loci on a given chromosome. P values estimated in conditional analyses are denoted by ‘Pcond in the main text; the SUGEN conditional results for all novel and secondary findings are shown in Supplementary Table 3.