Chunk #20 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN?
Since its earliest studies, COGA has found that low P300 amplitude, associated with AUD is also found in high‐risk offspring. 11 The initial studies in COGA reported lower P300 amplitudes to target stimuli in both visual and auditory oddball tasks in those with AUD and their offspring, albeit more consistently in visual tasks. 77 COGA have demonstrated that low parietal P300 to visual targets is more prevalent in members of dense AUD families, including their offspring compared to members of community comparison families. 11 , 98 More recently, COGA has demonstrated that higher family history density of AUD was associated with lower amplitude parietal P300, higher likelihood of AUD, and earlier onset of regular drinking. 32 Thus, the longitudinal study of family members with multimodal measures can elucidate the important relationship between neural measures and family density of AUD in affecting risk of developing AUD as well as allow for examining how social environment may moderate risk factors (further detail provided in Section 3.3). COGA was a pioneer in developing and implementing ERO methods to understand neural mechanisms underlying P300
