Consistent with the literature, heterotrimeric G-protein signaling (Gαi and Gαs-mediated) was identified as a major pathway targeted by cocaine. In addition to G-protein coupled receptors (GPCRs) for the major neurotransmitters (discussed below), neuropeptide (opioid, galanin, somatostatin), lipid, and cadherin-type GPCRs showed cocaine-related changes in expression (Table 3).
