The BSMN will generate an estimated 10,000 sequencing data sets that comprise >600 terabytes of data and facilitate data-sharing through the BSMN Knowledge Portal (www.synapse.org/bsmn) and the NIMH Data Archive (https://data-archive.nimh.nih.gov). Coordinated analyses with data derived from some of the same brain samples by the CommonMind (www.synapse.org/cmc) and PsychENCODE (www.synapse.org/pec) initiatives may elucidate the effect of somatic mosaicism on tissue-wide gene expression. Data generated though the BSMN initiative will be released to the broader research community on an ongoing basis through a controlled-access mechanism that follows NIH policies and regulatory requirements.