These results partially support past findings that the C allele of FAAH C385A confers risk for CD (Tyndale et al. 2007; Haughey et al. 2008). However, the lack of association with many of the measures examined and the association between the A allele and HR reactivity necessitate further phenotype refinement. Craving, withdrawal, and sensitivity to the acute effects of marijuana are promising intermediate phenotypes of CD and represent targets of opportunity in the search for candidate genes that may influence this disorder.
