There are two key features of the PANTHER pathway data model. First, the association between the molecule classes and protein sequences links the pathway to the phylogenetic relationships and statistical models (HMMs) of the protein families. As a result, if a protein is associated with a pathway component via experimental evidence, its orthologs can be inferred to the same component based on the PANTHER phylogenetic tree. Second, PANTHER pathway supports community standards, and all pathways are available in SBML26, BioPAX27 and SBGN25 formats.
